✦ 04 / EVIDENCE, NOT INFERENCE
The cell is the unit of proof.
ARCELL studies are designed around evidence that can be traced from specimen and cell to clone, phenotype and biological interpretation.
A LINEAGE-FIRST VIEW
Resolve the architecture before you explain the outcome.
Bulk signals can average away rare events. Separately measured single-cell assays can lose the relationship between clone and state. ARCELL's evidence framework centres the cell and documents how each conclusion is reached.
READING THE DATA
Clone structure
Cell-resolved CNA profiles identify coherent genetic lineages rather than cohort averages.
Persistence
Paired or longitudinal specimens can reveal which subclones remain through clinical time.
Interpretation
Genetic structure becomes the frame for testing state, dosage and mechanism.
THE EVIDENCE STANDARD
A useful result is one another scientist can interrogate.
ARCELL projects are designed to make assumptions visible: what entered the study, what passed quality control, what was measured in each cell and which analytical criteria supported the interpretation.
Talk through the evidence framework