Qualify
Evaluate block age, tumor content, fixation context and nuclear integrity before study entry.
✦ 02 / FFPE SINGLE-CELL DNA
Make the archive legible.
Arc-well is an archival single-cell genome workflow for turning FFPE pathology material into cell-resolved copy-number evidence and clonal history.
THE PROBLEM
Years of pathology can contain the beginning of the answer.
Formalin-fixed paraffin-embedded tissue captures clinical time. Arc-well is designed to return that time to research, supporting retrospective cohort studies from material that is usually treated as an endpoint rather than a starting point.
ARC-WELL WORKFLOW
Recover
Prepare nuclei and construct single-cell libraries from retained pathology specimens.
Resolve
Call genome-wide copy-number structure at cellular resolution and reconstruct clonal relationships.
STUDY USE CASES
Built for the questions time makes possible.
RETROSPECTIVE COHORTS
Bring multi-year pathology collections into a shared single-cell CNA research framework.
PRIMARY TO RECURRENCE
Compare paired disease timepoints to find persistent and emerging genomic subclones.
HISTORICAL MATERIAL
Use stored clinical specimens to test lineage hypotheses that could not be asked at collection.
Arc-well is intended for research applications. Sample suitability and achievable performance depend on tissue condition, clinical handling history and study design.
Assess a cohort with ARCELL