Which genomic clones carry distinct transcriptional programmes?
✦ 03 / SAME-CELL DNA + RNA
Keep genotype
and state in the same cell.
wellDR-seq is a same-cell DNA+RNA method for testing how genomic clone structure relates to transcriptional state without relying on cross-cell inference.
THE DISTINCTION
DNA identifies lineage. RNA reveals cellular state.
When they are measured apart, the relationship must be inferred.
wellDR-seq is built to retain both measurements in a common cellular record. It lets researchers describe a clone and its expression programme as evidence from the same biological unit.
DNA
GENOMIC
CLONE
CLONE
RNA
STATE
STATE
ONE CELL, TWO READOUTS
Evidence that stays paired.
- DNA
Genome-wide low-depth CNA for clone structure and lineage reconstruction.
- RNA
Transcriptional measurement for phenotype, programme and response state.
- PAIR
Same-cell correspondence for direct genotype-to-phenotype analysis.
MECHANISM-ORIENTED RESEARCH
Ask beyond cell clustering.
Do rare genomic events correspond to a reproducible RNA state?
Which dosage relationships persist after clonal structure is resolved?
wellDR-seq should be planned around a defined biological question, sample type and validation strategy.
Plan a same-cell study